Top 15 Angiotensin-Converting Enzyme (ACE) Inhibitors

In addition, ACE inhibitors were first introduced in the 1970s and have become one of the most commonly prescribed medications for hypertension. Healthcare providers often recommend them as first-line therapy for patients with coexisting conditions like diabetes, kidney disease, and heart failure. Also, studies have shown that ACE inhibitors when compared to other antihypertensive drug classes, reduce the risk of mortality and cardiovascular events.

This article will provide an overview of the top 15 most commonly used ACE inhibitors, their approved indications, available strengths, dosing recommendations, and notable drug interactions. Understanding the subtle differences between ACE inhibitors allows providers to choose the most appropriate agent for each patient.Angiotensin-Converting Enzyme (ACE) Inhibitors

The Top 15 Most Commonly Used ACE Inhibitors

The top 15 Angiotensin-Converting Enzyme (ACE) Inhibitors Are:

1. Lisinopril

Doctors most commonly prescribe Lisinopril as the leading choice among ACE inhibitors for patients with hypertension or heart failure. It is available in generic form making it affordable for most patients.

Uses: Hypertension, Heart Failure, Diabetic Kidney Disease
Available Strengths: 5mg, 10mg, 20mg, 30mg, 40mg
Usual Dosing: Start at 10mg once daily, the maximum dose is 40mg daily
Notable Drug Interactions: NSAIDs, Potassium supplements

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2. Enalapril

Another frequently used Angiotensin-Converting Enzyme inhibitor, Enalapril, has been available on the market for over 30 years. It provides around-the-clock blood pressure control with once or twice daily dosing.

Uses: Hypertension, Heart Failure
Available Strengths: 2.5mg, 5mg, 10mg, 20mg
Usual Dosing: Start at 5mg daily, maximum dose is 40mg daily
Notable Drug Interactions: Antacids

3. Ramipril

Also, Ramipril has the added benefit of reducing cardiovascular mortality in high-risk patients compared to some other ACE inhibitors. It should be taken consistently at the same time each day.NDLEA Apprehends Cyprus-Bound Student With Drugs

Uses: Hypertension, Heart Failure, Diabetic Kidney Disease, High Cardiovascular Risk
Available Strengths: 1.25mg, 2.5mg, 5mg, 10mg
Usual Dosing: Start at 2.5mg daily, maximum dose is 10mg daily
Notable Drug Interactions: Diuretics

4. Fosinopril

Fosinopril only requires once-daily dosing and is well tolerated by most patients. Also, it should be taken on an empty stomach for optimal absorption.Gabriel Martinelli injury update

Uses: Hypertension, Heart Failure
Available Strengths: 10mg, 20mg, 40mg
Usual Dosing: Start at 10mg daily, maximum dose is 40mg daily
Notable Drug Interactions: Antacids

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5. Captopril

Captopril has a relatively short duration of action compared to other ACE inhibitors. It must be taken 2-3 times per day for a full antihypertensive effect.

Uses: Hypertension, Heart Failure, Diabetic Kidney Disease
Available Strengths: 12.5mg, 25mg, 50mg, 100mg
Usual Dosing: Start at 12.5mg 2-3 times daily, maximum dose is 450mg daily
Notable Drug Interactions: NSAIDs

6. Benazepril

Benazepril is available in combination with amlodipine, a calcium channel blocker, for patients requiring multiple medications to control blood pressure.

Uses: Hypertension
Available Strengths: 5mg, 10mg, 20mg, 40mg; combination with amlodipine
Usual Dosing: Start at 10mg daily, maximum dose is 40mg daily
Notable Drug Interactions: Potassium supplements

7. Quinapril

Quinapril is an alternative ACE inhibitor that can be dosed once daily. It should be taken on an empty stomach for optimal absorption.Dollar to Naira

Uses: Hypertension
Available Strengths: 5mg, 10mg, 20mg, 40mg
Usual Dosing: Start at 10-20mg daily, the maximum dose is 80mg daily
Notable Drug Interactions: Diuretics

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8. Perindopril

Perindopril has a particularly long duration of action, providing full 24-hour blood pressure reduction with just a single daily dose.

Uses: Hypertension, Heart Failure, High Cardiovascular Risk
Available Strengths: 2mg, 4mg, 8mg
Usual Dosing: Start at 4mg daily, the maximum dose is 8mg daily
Notable Drug Interactions: Potassium-sparing diuretics

9. Trandolapril

Trandolapril requires slower titration than some other ACE inhibitors to minimize adverse effects. Blood pressure should be monitored regularly with dose adjustments.JAMB Result

Uses: Hypertension, Heart Failure, Diabetic Kidney Disease
Available Strengths: 1mg, 2mg, 4mg
Usual Dosing: Start at 1mg daily, increase slowly to a maximum of 4mg daily
Notable Drug Interactions: Lithium

10. Moexipril

Moexipril is dosed once daily but takes several weeks to have its maximum blood pressure-lowering effect. Existing hypertension medications should be continued when starting.NYSC Portal

Uses: Hypertension
Available Strengths: 7.5mg, 15mg
Usual Dosing: Start at 7.5mg daily, maximum dose is 15mg daily Notable Drug Interactions: Diuretics

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11. Zofenopril

Zofenopril is not yet available as a generic drug but provides potent, long-lasting ACE inhibition with once-daily dosing.

Uses: Hypertension
Available Strengths: 7.5mg, 15mg, 30mg
Usual Dosing: Start at 7.5mg daily, maximum dose is 60mg daily
Notable Drug Interactions: Lithium

12. Imidapril

Imidapril is not approved for use in the United States but is utilized in other countries. It also requires twice daily dosing for full therapeutic effect.Good Morning my love Messages

Uses: Hypertension
Available Strengths: 2.5mg, 5mg, 10mg
Usual Dosing: Start at 2.5mg twice daily, titrate up to 10mg twice daily
Notable Drug Interactions: Diuretics

13. Spirapril

Spirapril is only available in a few countries and is dosed twice daily. Also, it can take several weeks to work and doses may require careful titration.

Uses: Hypertension
Available Strengths: 6mg, 12mg, 24mg
Usual Dosing: Start at 6mg twice daily, maximum dose is 12mg twice daily
Notable Drug Interactions: Allopurinol

14. Temocapril

Temocapril is another ACE inhibitor not approved for use in the United States. Also, doses should be titrated slowly over several weeks for optimal blood pressure lowering.Romantic Love Messages for her 

Uses: Hypertension
Available Strengths: 2mg, 4mg, 8mg, 16mg
Usual Dosing: Start at 2mg daily, maximum dose is 16mg daily
Notable Drug Interactions: Antacids

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15. Cilazapril

Cilazapril is infrequently used but is a once-daily ACE inhibitor. Also, it should be taken on an empty stomach which can cause an upset stomach when first started.

Uses: Hypertension
Available Strengths: 1mg, 2.5mg, 5mg
Usual Dosing: Start at 1mg daily, maximum dose is 5mg per day
Notable Drug Interactions: Diuretics

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Conclusion

This article lists the top 15 ACE inhibitors used globally, with lisinopril, enalapril, and ramipril being among the most frequently prescribed. Newer agents like zofenopril offer potent, once-daily blood pressure reduction but are not yet available as generics. However, choosing the right ACE inhibitor for each patient requires understanding the pharmacokinetics, indications, dosing nuances, and interaction potential of these medications. With an appreciation for the subtleties of different ACE inhibitors, providers can optimize treatment and improve adherence for patients requiring this vital class of antihypertensive therapies.

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